Does Sertraline Affect Fertility?

If you’re taking sertraline (commonly known as Zoloft) and thinking about getting pregnant, you might be asking yourself:Will this affect my fertility? Should I stop taking it before trying to conceive?

It’s a really common question—and a valid one. Sertraline is one of the most prescribed antidepressants worldwide, and many people who take it are in their prime reproductive years. The good news? Most research shows that sertraline doesn’t significantly harm fertility—but there are a few things to consider when planning your next steps.

Let’s walk through what the science says, and how to make a choice that supports both your mental health and your fertility journey.

What Is Sertraline, and Why Does It Matter?

Sertraline is a type of antidepressant known as an SSRI (Selective Serotonin Reuptake Inhibitor). It’s used to treat depression, anxiety, PTSD, and other mood-related conditions.

Because mental health and reproductive health are deeply connected, staying emotionally well is an important part of preparing for pregnancy—not something to put on the back burner.

Does Sertraline Affect Female Fertility?

Current research suggests that sertraline doesn’t significantly impact ovulation or egg quality. Unlike some medications that suppress the menstrual cycle or hormone levels, SSRIs like sertraline generally do not disrupt your cycle.

That said, here are a few potential considerations:

• Some people report changes in libido or sexual function on SSRIs, which can affect timing and frequency of intercourse—but this doesn’t mean your fertility is impaired.

• In rare cases, SSRIs may be associated with slight changes in menstrual cycle length, but not to a degree that’s typically harmful to fertility.
  

What About Male Fertility?

Some studies suggest that SSRIs—including sertraline—may affect sperm parameters, such as:

• Reduced motility (how well sperm swim)

• Slight changes in sperm morphology (shape)

However, these effects vary from person to person and are often reversible if the medication is stopped. If you're concerned, a semen analysis is a simple first step.

But here’s the thing: managing depression and anxiety is also essential to healthy sexual function, hormone regulation, and relationship dynamics. If sertraline helps with that, the benefits often outweigh the potential risks.

Should I Stop Taking Sertraline Before TTC?

Not necessarily. For many, staying on sertraline is safer than stopping suddenly or experiencing a relapse. Discontinuing an SSRI can cause withdrawal symptoms and worsen anxiety or depression—especially during the emotionally intense fertility process.

If you’re considering making changes:

• Always talk to your doctor before stopping or switching medications

• You may explore lower doses or alternative therapies with your provider

• Never stop abruptly—tapering is key

Mental health is fertility health.

Final Thoughts

Sertraline is not a fertility blocker—but your emotional well-being is part of your reproductive story. If this medication helps you feel balanced and functional, it may be worth continuing with the support of your doctor.

👉 Inside our Fertility 101 course, we walk through fertility factors holistically—including how to navigate medications, testing, and emotional wellness with confidence.

You deserve support that honours your whole health—and we’re here for all of it.

FAQ

Does sertraline affect ovulation or egg quality?
There’s no strong evidence that sertraline disrupts ovulation or reduces egg quality.

Can men taking sertraline still conceive?
Yes—but if concerned, a semen analysis can check for any medication-related changes.

Is it safe to stay on sertraline during pregnancy?
For many people, yes—but always talk to your doctor. Staying on the medication may be safer than stopping.

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