How to Take Letrozole for Fertility: Dosage & Tips [2025]

If you’ve been prescribed Letrozole (Femara) to help you ovulate, you’re not alone. Many women navigating irregular cycles, PCOS, or unexplained infertility are offered this medication as a first step toward boosting ovulation. But knowing exactly how to take Letrozole—and what to expect along the way—can help you feel more confident and in control.

At fertie, we believe in making fertility treatments clearer, less overwhelming, and more empowering. So here’s your simple, expert-backed guide to using Letrozole for ovulation induction.

What Is Letrozole and How Does It Work?

Letrozole is part of a group of medications called aromatase inhibitors. Originally used in breast cancer treatment, it’s now commonly prescribed in fertility care to help women ovulate regularly.

Here’s how it works:
Letrozole lowers estrogen levels temporarily. This signals your brain (specifically your pituitary gland) to release more FSH (Follicle-Stimulating Hormone). FSH encourages your ovaries to develop and mature follicles—which is where your eggs are released from.

The goal? To trigger healthy ovulation, increasing your chances of conception.

Why Do Doctors Recommend Letrozole?

Many fertility specialists prescribe Letrozole because:

• It’s often effective in women with PCOS, irregular cycles, or unexplained infertility

• It has a lower risk of multiples (twins or more) than Clomid

• It’s generally well-tolerated with fewer side effects for most women

• It may be an option for women who didn’t respond to Clomid or want a different approach

The Typical Letrozole Protocol: What to Expect

Letrozole is usually taken early in your cycle for a short period.

Here’s a general outline (but always follow your doctor’s instructions!):

1. Dosage

• Most women are prescribed between 2.5mg and 7.5mg per day.
  

• Your doctor may adjust your dosage depending on how your body responds.

2. When to Take It

• Letrozole is commonly taken on cycle days 3–7 or 5–9.
  

• You’ll take it once daily for 5 consecutive days.

3. Monitoring Ovulation

After finishing your medication, your clinic may:

• Perform ultrasounds to track follicle growth.
  

• Recommend ovulation predictor kits (OPKs) to detect an LH surge.
  

• Run blood tests (like progesterone checks) to confirm ovulation occurred.

4. Timing Intercourse or Insemination

Your doctor will guide you on when to have sex (or schedule an IUI) based on ovulation timing. Many people ovulate about a week after finishing Letrozole.

Possible Side Effects of Letrozole

Most people tolerate Letrozole well, but some experience mild side effects, including:

• Hot flashes

• Headaches

• Mood swings

• Breast tenderness

• Mild bloating

• Rarely, ovarian cysts can develop

If you notice any severe side effects or feel unsure, always check in with your clinic.

FAQs About Taking Letrozole for Fertility

How many cycles of Letrozole should I try?
Many doctors recommend trying Letrozole for 3–6 cycles before exploring other treatments. This depends on your age, fertility diagnosis, and how you respond.

Can Letrozole increase pregnancy chances?
Yes! Studies show that Letrozole can be more effective than Clomid for ovulation induction in women with PCOS. Success rates vary, but many women conceive within the first few cycles.

Does Letrozole increase the risk of twins?
There’s a low risk (less than 10%) of conceiving multiples with Letrozole, which is lower than with Clomid.

Final Thoughts: You’ve Got This

Taking Letrozole can feel like a big step—but understanding how it works and what to expect can make it less intimidating. Whether this is your first cycle or one of many, remember: you’re not alone on this journey.

At fertie, we’re here to support you with expert-backed courses, community, and compassion.

👉 Our Fertility 101 Course includes detailed medication guides (including Letrozole!), step-by-step timelines, and expert advice—so you can feel informed and empowered every step of the way.

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Disclaimer: This post is for educational purposes only and is not a substitute for medical advice. Always consult your healthcare provider for personalized guidance.